In recent years, the wellness and skincare communities have been abuzz about NAD+, a vital coenzyme involved in cellular energy production. From anti-aging clinics to skincare product lines, NAD+ has become a hot topic. But what exactly is all the fuss about? And how can replenishing NAD+ help preserve youthful skin and promote longevity? Let's dive into the science behind the hype and explore why NAD+ might be your skin’s new best friend.
What is NAD+ and Why Is It Important?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells. It plays a crucial role in converting nutrients into energy, supporting DNA repair, and maintaining cellular health. As we age, NAD+ levels naturally decline, impairing cellular function and accelerating the aging process [1].
The Rising Popularity of NAD+ in Longevity and Skincare
Research suggests that boosting NAD+ levels can enhance mitochondrial function, increase cells' ability to repair damage, and activate longevity pathways. This understanding has fueled interest in NAD+ supplementation and skincare products designed to support or stimulate NAD+ production [2].
How NAD+ Replenishment Benefits Skin Aging
- Supports DNA Repair: Sun exposure and environmental stressors damage skin DNA, leading to wrinkles and fine lines. NAD+ is essential for activating enzymes like PARPs that repair this damage [3].
- Enhances Cell Energy: Well-nourished skin cells produce more collagen and elastin, key proteins that keep skin firm and supple. NAD+ boosts cellular energy, promoting a vibrant, youthful appearance [4].
- Reduces Oxidative Stress: NAD+ activates sirtuins—proteins that combat oxidative damage, a major contributor to skin aging [5].
- Activates Longevity Pathways: NAD+ stimulates pathways associated with cellular renewal and longevity, supporting healthier skin over time [6].
Emerging Strategies for NAD+ Replenishment
- Supplementation: NAD+ precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) from Renue By Science are popular supplements that can increase circulating NAD+ levels [7].
- Topical Products: Skincare formulations infused with NAD+ precursors like the Renue BLUE Face Serum aim to deliver benefits directly to the skin barrier [8].
- Lifestyle Factors: Regular exercise, caloric restriction, and avoiding excessive sun exposure can naturally support NAD+ levels [9].
References:
[1]: Bogan, K. L., & Brenner, C. (2008). Nicotinic acid, nicotinamide, and nicotinamide riboside: a review of their metabolism and effects on NAD+ homeostasis. Progress in Lipid Research, 47(4), 318–336. https://doi.org/10.1016/j.plipres.2008.04.002
[2]: Yoshino, J., & Imai, S. (2020). NAD+ Interventions for Aging and Age-Related Diseases. Cell Metabolism, 31(2), 260-278. https://doi.org/10.1016/j.cmet.2020.01.009
[3]: Mouchiroud, L., et al. (2013). NAD+ supplementation restores mitochondrial function and reduces oxidative stress in aging. Nature Communications, 4, 1484. https://doi.org/10.1038/ncomms2514
[4]: Verdin, E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208-1213. https://doi.org/10.1126/science.aac7853
[5]: Houtkooper, R. H., et al. (2012). Sirtuins as regulators of metabolism and healthspan. Nature Reviews Molecular Cell Biology, 13(4), 225–238. https://doi.org/10.1038/nrm3308
[6]: Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and healthspan. Cell, 159(3), 431–434. [