Transdermal delivery is a method of applying active ingredients through the skin. It's convenient and can improve ingredient delivery, absorption and effectiveness. The skin's protective barrier creates a challenge for transdermal delivery. As a result, liposomes can be used to carry ingredients past the skin's barrier. (Source)
Liposomes
Liposomes are an advanced delivery vehicle, protecting a much higher percentage of active ingredients from digestion, while slowly releasing the payload into the bloodstream.
- Liposomes improve permeation of products to the site where applied, for localized treatment (in the skin)
- Liposomes also offer systemic nutrient delivery (in the body)
- Liposomal topicals and transdermals can optimize cellular uptake and effectiveness
What Liposomes Are Made Of
A Liposome is made up of a spherical vesicle with the inner contents containing the active ingredients, which are protected by an outer layer comprised of tiny fat-like particles, called the Phospholipid Layer. Liposomes have the ability to carry ingredients that are hydrophobic ("water-fearing") and hydrophilic ("water-loving"). (Source)
Advantages to Transdermal Liposomal Delivery
- Superior stability of active ingredients
- Higher absorption and greater efficacy
- May circumvent first-pass metabolism - meaning, more of the nutrients will reach your bloodstream
- Enhanced skin permeability, allowing more actives past the outer layer & deeper into the cells
- The dose is slowly released so the supplement's concentration level can stay fairly constant in the body
Safety of Liposomal Delivery
Liposomes closely resemble the structure of cell membranes, and as a result the body recognizes them as safe and friendly substances (they are biocompatible). Liposome-formulated drugs are used routinely to treat a wide range of illnesses. Nutraceutical or nutritional liposomes can act as both a treatment as well as preventive care. The nutritional industry’s use of liposomes is expected to grow rapidly in the next 5–10 years. (Source, Source)
"Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier systems known to date." - International Journal of Nanomedicine, Liposomes As Nanomedical Devices
How Are they Absorbed?
Some liposomes work to deliver nutrients by diffusion, meaning the surface of the skin (stratum corneum) absorbs them, and then transfers the active ingredients directly from the liposomes to the skin. In addition, lecithin in often used in liposome formulations and it increases the permeability of the skin's surface or barrier, enhancing transdermal delivery. (Source)
The inclusion of lipid vesicles into lotions can enhance their stability, prolong active product release, enhance transdermal permeability, and increase localization of the active within the skin. - Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery
Why Renue Blue by Renue by Science
The delivery method is vital when it comes to skincare. What sets the Renue Blue skincare line apart, in addition to the potent ingredients and scientifically advanced formulation, is its superior mode of delivery. Liposomes safely carry the active ingredients, which include a NAD+ Complex (NAD+, NMN & NR), Resveratrol and Apocynin, past the outer skin barrier and deep into your cells. The formulation allows for these potent ingredients to reach the target site before releasing them to offer a targeted skin treatment. Learn More.